Sebhat, I. : rechercher sur Z-Library

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1

A role for the melanocortin 4 receptor in sexual function

Van der Ploeg, L. H. T., Martin, W. J., Howard, A. D., Nargund, R. P., Austin, C. P., Guan, X., Drisko, J., Cashen, D., Sebhat, I., Patchett, A. A., Figueroa, D. J., DiLella, A. G., Connolly, B. M., W

Journal:

Proceedings of the National Academy of Sciences

Année:

2002

Langue:

english

Fichier:

PDF, 345 KB

english, 2002

2

Comparison of Analytical Methods to Determine Sodium Content of Low-Sodium Foods

Ehling, Stefan, Tefera, Sebhat, Earl, Robert, Cole, Shannon

Journal:

Journal of AOAC International

Année:

2010

Fichier:

PDF, 416 KB

2010

3

Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist

Brenda L. Palucki, Min K. Park, Ravi P. Nargund, Zhixiong Ye, Iyassu K. Sebhat, Patrick G. Pollard, Rubana N. Kalyani, Rui Tang, Tanya MacNeil, David H. Weinberg, Aurawan Vongs, Charles I. Rosenblum,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 291 KB

english, 2005

4

Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials

Kausik K Ray, Sreenivasa Rao Kondapally Seshasai, Shanelle Wijesuriya, Rupa Sivakumaran, Sarah Nethercott, David Preiss, Sebhat Erqou, Naveed Sattar

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 227 KB

english, 2009

5

Stress Testing and Risk Prediction in People With Known Symptomatic Multivessel Coronary Artery Disease

Erqou, Sebhat, Soares, Cullen, Wu, Wen-Chih

Journal:

JAMA Internal Medicine

Année:

2020

Langue:

english

Fichier:

PDF, 70 KB

english, 2020

6

Determination of brain and plasma drug concentrations by liquid chromatography/tandem mass spectrometry

C. S. Tamvakopoulos, L. F. Colwell, K. Barakat, J. Fenyk-Melody, P. R. Griffin, R. Nargund, B. Palucki, I. Sebhat, X. Shen, R. A. Stearns

Journal:

Rapid Communications in Mass Spectrometry

Année:

2000

Langue:

english

Fichier:

PDF, 92 KB

english, 2000

7

ChemInform Abstract: Synthesis of the Antitumor Alkaloid (+)-Pancratistatin Using the β-Azidonation Reaction via a Prochiral 4-Arylcyclohexanone Derivative.

P. MAGNUS, I. K. SEBHAT

Journal:

Année:

1998

Fichier:

PDF, 38 KB

1998

8

ChemInform Abstract: Application of the β-Azidonation Reaction to the Synthesis of the Antitumor Alkaloid (+)-Pancratistatin.

Philip Magnus, Iyassu K. Sebhat

Journal:

Année:

1999

Fichier:

PDF, 34 KB

1999

9

ChemInform Abstract: Directed Lithiation in Arenetricarbonylchromium(0) Complexes: Assessment of Some Directing Group Specificities and of Electrophilic Quench Efficacies.

Iyassu K. Sebhat, Yen-Ling Tan, David A. Widdowson, Rene Wilhelm, Andrew J. P. White, David J. Williams

Journal:

Année:

2000

Fichier:

PDF, 35 KB

2000

10

1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: Application in the synthesis of potent human melanocortin-4 receptor selective agonists

Raman K. Bakshi, Qingmei Hong, J.T. Olson, Zhixiong Ye, Iyassue K. Sebhat, David H. Weinberg, Tanya MacNeil, Rubana N. Kalyani, Rui Tang, William J. Martin, Alison Strack, Erin McGowan, Constantin Tam

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 188 KB

english, 2005

11

Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist

Zhixiong Ye, Liangqin Guo, Khaled J. Barakat, Patrick G. Pollard, Brenda L. Palucki, Iyassu K. Sebhat, Raman K. Bakshi, Rui Tang, Rubana N. Kalyani, Aurawan Vongs, Airu S. Chen, Howard Y. Chen, Charle

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 273 KB

english, 2005

12

Melanocortin subtype 4 receptor agonists: Structure–activity relationships about the 4-alkyl piperidine core

Iyassu K. Sebhat, Yingjie Lai, Khaled Barakat, Zhixiong Ye, Rui Tang, Rubana N. Kalyani, Aurawan Vongs, Tanya MacNeil, David H. Weinberg, M. Angeles Cabello, Marta Maroto, Ana Teran, Tung M. Fong, Lex

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 153 KB

english, 2007

13

Synthesis and SAR of potent and orally bioavailable tert-butylpyrrolidine archetype derived melanocortin subtype-4 receptor modulators

Liangqin Guo, Zhixiong Ye, Feroze Ujjainwalla, Heather L. Sings, Iyassu K. Sebhat, John Huber, David H. Weinberg, Rui Tang, Tanya MacNeil, Constantin Tamvakopoulos, Qianping Peng, Euan MacIntyre, Lex

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 163 KB

english, 2008

14

Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists

Shuwen He, Peter H. Dobbelaar, Jian Liu, Tianying Jian, Iyassu K. Sebhat, Linus S. Lin, Allan Goodman, Cheng Guo, Peter R. Guzzo, Mark Hadden, Alan J. Henderson, Megan Ruenz, Bruce J. Sargent, Larry Y

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 560 KB

english, 2010

15

Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist

Shuwen He, Zhixiong Ye, Peter H. Dobbelaar, Iyassu K. Sebhat, Liangqin Guo, Jian Liu, Tianying Jian, Yingjie Lai, Christopher L. Franklin, Raman K. Bakshi, James P. Dellureficio, Qingmei Hong, Nancy N

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 454 KB

english, 2010

16

Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity

Jian Liu, Shuwen He, Tianying Jian, Peter H. Dobbelaar, Iyassu K. Sebhat, Linus S. Lin, Allan Goodman, Cheng Guo, Peter R. Guzzo, Mark Hadden, Alan J. Henderson, Kevin Pattamana, Megan Ruenz, Bruce J

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 927 KB

english, 2010

17

Synthesis and SAR of heterocyclic carboxylic acid isosteres based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity

Mark Hadden, Allan Goodman, Cheng Guo, Peter R. Guzzo, Alan J. Henderson, Kevin Pattamana, Megan Ruenz, Bruce J. Sargent, Brian Swenson, Larry Yet, Jian Liu, Shuwen He, Iyassu K. Sebhat, Linus S. Lin,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1.99 MB

english, 2010

18

Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands

Qingmei Hong, Raman K. Bakshi, James Dellureficio, Shuwen He, Zhixiong Ye, Peter H. Dobbelaar, Iyassu K. Sebhat, Liangqin Guo, Jian Liu, Tianying Jian, Rui Tang, Rubana N. Kalyani, Tanya MacNeil, Aura

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 293 KB

english, 2010

19

Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4′-piperidine] based melanocortin subtype-4 receptor agonists

Liangqin Guo, Zhixiong Ye, Jian Liu, Shuwen He, Raman K. Bakshi, Iyassu K. Sebhat, Peter H. Dobbelaar, Qingmei Hong, Tianying Jian, James P. Dellureficio, Nancy N. Tsou, Richard G. Ball, David H. Wein

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1.05 MB

english, 2010

20

Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity

Shuwen He, Zhixiong Ye, Peter H. Dobbelaar, Iyassu K. Sebhat, Liangqin Guo, Jian Liu, Tianying Jian, Yingjie Lai, Christopher L. Franklin, Raman K. Bakshi, James P. Dellureficio, Qingmei Hong, David H

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1.94 MB

english, 2010

21

Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity

Shuwen He, Zhixiong Ye, Peter H. Dobbelaar, Raman K. Bakshi, Qingmei Hong, James P. Dellureficio, Iyassu K. Sebhat, Liangqin Guo, Jian Liu, Tianying Jian, Yingjie Lai, Christopher L. Franklin, Mikhail

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1.34 MB

english, 2010

22

Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist

Qingmei Hong, Raman K. Bakshi, Brenda L. Palucki, Min K. Park, Zhixiong Ye, Shuwen He, Patrick G. Pollard, Iyassu K. Sebhat, Jian Liu, Liangqin Guo, Doreen E. Cashen, William J. Martin, David H. Weinb

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 551 KB

english, 2011

23

Preparation of 2,3-dihydro-1H-spiro[isoquinoline-4,4′-piperidine] via an N-sulfonyl Pictet–Spengler reaction

Jian Liu, Tianying Jian, Iyassu Sebhat, Ravi Nargund

Journal:

Tetrahedron Letters

Année:

2006

Langue:

english

Fichier:

PDF, 99 KB

english, 2006

24

Directed Lithiation in Arenetricarbonylchromium(0) Complexes: Assessment of Some Directing Group Specificities and of Electrophilic Quench Efficacies

Iyassu K. Sebhat, Yen-Ling Tan, David A. Widdowson, René Wilhelm, Andrew J.P. White, David J. Williams

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 239 KB

english, 2000

25

Asymmetric deprotonation—substitution of arenetricarbonylchromium(0) complexes: substituent controlled lithiation with the butyllithium–sparteine system

René Wilhelm, Iyassu K. Sebhat, Andrew J.P. White, David J. Williams, David A. Widdowson

Journal:

Tetrahedron: Asymmetry

Année:

2000

Langue:

english

Fichier:

PDF, 190 KB

english, 2000

26

Application of the β-azidonation reaction to the synthesis of the antitumor alkaloid (+)-pancratistatin

Philip Magnus, Iyassu K. Sebhat

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 965 KB

english, 1998

27

Health-related lifestyle in adults and children with primary immune thrombocytopenia (ITP)

Ameet Sarpatwari, Shirley Watson, Sebhat Erqou, Howard Anderson, John Grainger, Julian P. T. Higgins, Adrian C. Newland

Journal:

British Journal of Haematology

Année:

2010

Langue:

english

Fichier:

PDF, 118 KB

english, 2010

28

Autologous 111In-labelled platelet sequestration studies in patients with primary immune thrombocytopenia (ITP) prior to splenectomy: a report from the United Kingdom ITP Registry

Ameet Sarpatwari, Drew Provan, Sebhat Erqou, Ravin Sobnack, Foong Way David Tai, Adrian C. Newland

Journal:

British Journal of Haematology

Année:

2010

Langue:

english

Fichier:

PDF, 486 KB

english, 2010

29

AMPK activators – potential therapeutics for metabolic and other diseases

G. Zhou, I. K. Sebhat, B. B. Zhang

Journal:

Acta Physiologica

Année:

2009

Langue:

english

Fichier:

PDF, 621 KB

english, 2009

30

A new class of prolylcarboxypeptidase inhibitors, Part 1: Discovery and evaluation

Thomas H. Graham, Wensheng Liu, Andreas Verras, Iyassu K. Sebhat, Yusheng Xiong, Kelly Bleasby, Urmi R. Bhatt, Qing Chen, Margarita Garcia-Calvo, Wayne M. Geissler, Judith N. Gorski, Huaibing He, Mich

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 3.12 MB

english, 2012

31

Activation of melanocortin MC4 receptors increases erectile activity in rats ex copula

William J Martin, Erin McGowan, Doreen E Cashen, Liza T Gantert, Jennifer E Drisko, Gary J Hom, Ravi Nargund, Iyassu Sebhat, Andrew D Howard, Lex H.T Van der Ploeg, D.Euan MacIntyre

Journal:

European Journal of Pharmacology

Année:

2002

Langue:

english

Fichier:

PDF, 306 KB

english, 2002

32

Intensive glycemic control and the risk of heart failure in patients with type 2 diabetes

Sebhat Erquo, Chee-Tin Christine Lee, Amanda Adler

Journal:

American Heart Journal

Année:

2012

Langue:

english

Fichier:

PDF, 51 KB

english, 2012

33

Intensive glucose control and cardiovascular outcomes – Authors' reply

Kausik K Ray, Sreenivasa RK Sheshasai, Sebhat Erqou, David Preiss, Naveed Sattar

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 86 KB

english, 2009

34

A 61 YEAR DIABETIC MAN WITH METHICILLIN-SENSITIVE STAPHYLOCOCCUS AUREUS SEPTIC ARTHRITIS AND ACUTE RENAL FAILURE: A CASE OF IGA-DOMINANT POSTINFECTIOUS GLOMERULONEPHRITIS

Erqou, Sebhat, Kamat, Nitin, Moschos, Stergios, Im, Annie, Bastacky, Sheldon

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 471 KB

english, 2012

35

Apolipoprotein(a) Isoforms and the Risk of Vascular Disease: Systematic Review of 40 Studies Involving 58,000 Participants

Sebhat Erqou, Alexander Thompson, Emanuele Di Angelantonio, Danish Saleheen, Stephen Kaptoge, Santica Marcovina, John Danesh

Journal:

Journal of the American College of Cardiology

Année:

2010

Langue:

english

Fichier:

PDF, 563 KB

english, 2010

36

Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity

Sebhat, Iyassu K., Franklin, Christopher, Lo, Michael M.-C., Chen, David, Jewell, James P., Miller, Randy, Pang, Jianmei, Palyha, Oksana, Kan, Yanqing, Kelly, Theresa M., Guan, Xiao-Ming, Marsh, Donal

Journal:

ACS Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 1.18 MB

english, 2011

37

Synthesis of the Antitumor Alkaloid (+)-Pancratistatin Using the β-Azidonation Reaction via a Prochiral 4-Arylcyclohexanone Derivative

Magnus, Philip, Sebhat, Iyassu K.

Journal:

Journal of the American Chemical Society

Année:

1998

Langue:

english

Fichier:

PDF, 148 KB

english, 1998

38

Meta-Analysis of Ventricular Premature Complexes and Their Relation to Cardiac Mortality in General Populations

Ataklte, Feven, Erqou, Sebhat, Laukkanen, Jari, Kaptoge, Stephen

Journal:

The American Journal of Cardiology

Année:

2013

Langue:

english

Fichier:

PDF, 371 KB

english, 2013

39

Design and Pharmacology of N -[(3 R )-1,2,3,4-Tetrahydroisoquinolinium- 3-ylcarbonyl]-(1 R )-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1 H -1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine ( 1 ), a Potent, Selective, Melanocortin Subtype-4 Receptor Agonist

Sebhat, Iyassu K., Martin, William J., Ye, Zhixiong, Barakat, Khaled, Mosley, Ralph T., Johnston, David B. R., Bakshi, Raman, Palucki, Brenda, Weinberg, David H., MacNeil, Tanya, Kalyani, Rubana N., T

Journal:

Journal of Medicinal Chemistry

Année:

2002

Langue:

english

Fichier:

PDF, 132 KB

english, 2002

40

Cardiovascular Comorbidity in COPD

Müllerova, Hana, Agusti, Alvar, Erqou, Sebhat, Mapel, Douglas W.

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 1.59 MB

english, 2013

41

Therapy for Hepatitis C Virus Infection Increases Survival of Patients With Pretreatment Anemia

Mohanty, Arpan, Erqou, Sebhat, McGinnis, Kathleen A., Vanasse, Gary, Freiberg, Matthew S., Sherman, Kenneth E., Butt, Adeel A.

Journal:

Clinical Gastroenterology and Hepatology

Année:

2013

Langue:

english

Fichier:

PDF, 1.25 MB

english, 2013

42

[Annual Reports in Medicinal Chemistry] Volume 38 || Chapter 4. Melanocortin-4 receptor agonists and antagonists: Chemistry and potential therapeutic utilities

Année:

2003

Langue:

english

Fichier:

PDF, 682 KB

english, 2003

43

Statins and glycaemic control in individuals with diabetes: a systematic review and meta-analysis

Erqou, Sebhat, Lee, C. Christine, Adler, Amanda I.

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 334 KB

english, 2014

44

Association between glycated haemoglobin and the risk of congestive heart failure in diabetes mellitus: systematic review and meta-analysis

Erqou, Sebhat, Lee, Chee-Tin Christine, Suffoletto, Matthew, Echouffo-Tcheugui, Justin B., de Boer, Rudolf A., van Melle, Joost P., Adler, Amanda I.

Journal:

European Journal of Heart Failure

Année:

2013

Langue:

english

Fichier:

PDF, 303 KB

english, 2013

45

Risk factors: Lipoprotein(a) and coronary disease—moving closer to causality

Danesh, John, Erqou, Sebhat

Journal:

Nature Reviews Cardiology (formerly Nature Clinical Practice Cardiovascular Medicine)

Année:

2009

Langue:

english

Fichier:

PDF, 251 KB

english, 2009

46

Antiobesity Effect of MK-5046, a Novel Bombesin Receptor Subtype-3 Agonist

Guan, X.-M., Metzger, J. M., Yang, L., Raustad, K. A., Wang, S.-P., Spann, S. K., Kosinski, J. A., Yu, H., Shearman, L. P., Faidley, T. D., Palyha, O., Kan, Y., Kelly, T. M., Sebhat, I., Lin, L. S., D

Journal:

Journal of Pharmacology and Experimental Therapeutics

Année:

2011

Langue:

english

Fichier:

PDF, 3.93 MB

english, 2011

47

Predictors of Mortality among United States Veterans with Human Immunodeficiency Virus and Hepatitis C Virus Coinfection

Erqou, Sebhat, Mohanty, Arpan, Murtaza Kasi, Pashtoon, Butt, Adeel A.

Journal:

ISRN Gastroenterology

Année:

2014

Langue:

english

Fichier:

PDF, 185 KB

english, 2014

48

Small Molecule Ligands of the Human Melanocortin-4 Receptor

Feroze Ujjainwalla, Bentham Science Publisher, Iyassu K. Sebhat, Bentham Science Publisher

Journal:

Current Topics in Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 446 KB

english, 2007

49

Pharmacokinetics of a Testosterone Gel in Healthy Postmenopausal Women

Singh, Atam B., Lee, Martin L., Sinha-Hikim, Indrani, Kushnir, Mark, Meikle, Wayne, Rockwood, Al, Afework, Sebhat, Bhasin, Shalender

Journal:

Journal of Clinical Endocrinology & Metabolism

Année:

2006

Langue:

english

Fichier:

PDF, 337 KB

english, 2006

50

Assessing the Risk of Progression From Asymptomatic Left Ventricular Dysfunction to Overt Heart Failure

Echouffo-Tcheugui, Justin B., Erqou, Sebhat, Butler, Javed, Yancy, Clyde W., Fonarow, Gregg C.

Journal:

Journal of the American College of Cardiology: Heart Failure

Année:

2015

Langue:

english

Fichier:

PDF, 1.47 MB

english, 2015